Table 1.
Patient characteristics
| Patients (n=337) | SLC22A18 expression | |||
|---|---|---|---|---|
|
| ||||
| Low (n=233) | High (n=104) | p-value | ||
| Age, n (%) | 0.966 | |||
| <65 years | 142 (42.1%) | 98 (42.1%) | 44 (42.3%) | |
| ≥65 years | 195 (57.9%) | 135 (57.9%) | 60 (57.7%) | |
| Gender, n (%) | 0.008 | |||
| Male | 207 (61.4%) | 154 (66.1%) | 53 (51.0%) | |
| Female | 130 (38.6%) | 79 (33.9%) | 51 (49.0%) | |
| Preoperative CEA level, n (%) | 0.015 | |||
| <5 ng/ml | 206 (61.1%) | 137 (58.8%) | 69 (66.3%) | |
| ≥5 ng/ml | 108 (32.0%) | 86 (36.9%) | 22 (21.2%) | |
| unknown | 23 (6.8%) | 10 (4.3%) | 13 (12.5%) | |
| Primary tumor location, n (%) | 0.390 | |||
| Right colon | 72 (21.4%) | 46 (19.7%) | 26 (25.0%) | |
| Left colon | 143 (42.4%) | 101 (43.3%) | 42 (40.4%) | |
| Rectum | 122 (36.2%) | 86 (36.9%) | 36 (34.6%) | |
| Tumor stage, n (%) | <0.001 | |||
| I | 76 (22.6%) | 37 (15.9%) | 39 (37.5%) | |
| II | 87 (25.8%) | 60 (25.8%) | 27 (26.0%) | |
| III | 91 (27.0%) | 64 (27.5%) | 27 (26.0%) | |
| IV | 83 (24.6%) | 72 (30.9%) | 11 (10.6%) | |
| Cell type, n (%) | 0.001 | |||
| WD/MD | 305 (90.5%) | 203 (87.1%) | 102 (98.1%) | |
| PD/MUC/SRC | 32 (9.5%) | 30 (12.9%) | 2 (1.9%) | |
| Vascular invasion, n (%) | 0.021 | |||
| Positive | 44 (13.1%) | 37 (15.9%) | 7 (6.7%) | |
| Negative | 293 (86.9%) | 196 (84.1%) | 97 (93.3%) | |
| Lymphatic invasion, n (%) | 0.091 | |||
| Positive | 85 (25.2%) | 65 (27.9%) | 20 (19.2%) | |
| Negative | 252 (74.8%) | 168 (72.1%) | 84 (80.8%) | |
| Perineural invasion, n (%) | 0.666 | |||
| Positive | 17 (7.3%) | 17 (7.3%) | 9 (8.7%) | |
| Negative | 311 (92.3%) | 216 (92.7%) | 95 (91.3%) | |