Table 1.

The top 32 kinetochore/centromere genes down-regulated upon inhibition of geranylgeranyl biosynthesis in MDA-MB-231 cells

Gene	Gene description	Down-regulated by AT (fold of control)	Rescued by GGOH (fold of control)
SPC25	SPC25, NDC80 kinetochore complex component	0.05	1.19
KIFC1	kinesin family member C1	0.06	0.92
CENPM	centromere protein M	0.06	0.99
SGOL1	shugoshin-like 1	0.06	0.97
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.07	1.26
PLK1	polo-like kinase 1	0.07	1.02
KIF2C	kinesin family member 2C	0.07	1.19
BIRC5	baculoviral IAP repeat-containing 5	0.07	0.99
NDC80	NDC80 homolog, kinetochore complex component	0.07	1.56
AURKB	aurora kinase B	0.08	1.04
BUB1	budding uninhibited by benzimidazoles 1 homolog	0.08	1.19
NUF2	NUF2, NDC80 kinetochore complex component	0.08	1.34
KIF4A	kinesin family member 4A	0.08	1.49
CENPA	centromere protein A	0.09	1.11
KIF18B	kinesin family member 18B	0.09	1.15
CENPF	centromere protein F, 350/400 ka (mitosin)	0.10	1.33
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta	0.11	1.42
KIF15	kinesin family member 15	0.11	1.21
ZWINT	ZW10 interactor	0.11	1.06
KIF23	kinesin family member 23	0.12	1.20
AURKA	aurora kinase A	0.12	0.78
CENPI	Centromere protein I	0.13	1.66
KIF11	Kinesin family member 11	0.14	1.43
MAD2L1	MAD2 mitotic arrest deficient-like 1	0.14	0.69
PLK4	polo-like kinase 4	0.14	0.75
KIF20B	Kinesin family member 20B	0.14	1.77
SPC24	SPC24, NDC80 kinetochore complex component	0.15	0.80
CENPE	centromere protein E, 312 kDa	0.16	0.71
KIF18A	Kinesin family member 18A	0.18	1.62
SGOL2	shugoshin-like 2	0.18	0.83
SKA3	spindle and kinetochore associated complex subunit 3	0.18	1.28
SKA1	spindle and kinetochore associated complex subunit 1	0.19	1.60