Table 2.
IC50 levels of venetoclax, GSK1059615 and PIK-75 treatments in patient samples
| Patient ID | Venetoclax (nM) | GSK1059615 (nM) | PIK-75 (nM)* |
|---|---|---|---|
| PT1 | 5.2 | >2000 | 121.2 |
| PT2 | 2.6 | 110.7 | 6.8 |
| PT3 | 2.8 | 458.4 | 5.9 |
| PT4 | 4.6 | 687.1 | 16.4 |
| PT5 | 2.2 | 707.0 | 20.9 |
| PT6 | 2.4 | 1003.0 | 35.2 |
| PT7 | 5.7 | >2000 | 84.9 |
| PT8 | 22.0 | >2000 | 335.8 |
| PT9 | 58.4 | >2000 | 347.1 |
| PT10 | 125.1 | 1574.0 | 28.8 |
| PT11 | 244.8 | >2000 | 428.1 |
| PT12 | 596.2 | >2000 | 123.0 |
| PT13 | 986.1 | >2000 | 344.9 |
| PT14 | 1159.0 | 2024.0 | 231.7 |
| PT15 | 1141.0 | >2000 | 52.0 |
| PT16 | 1243.0 | 943.0 | 92.2 |
| PT17 | 685.9 | 1971.0 | 20.9 |
| PT18 | >2000 | 3030.0 | 16.4 |
| PT19 | >2000 | 1311.0 | 74.5 |
| PT20 | >2000 | >2000 | 29.9 |
| PT21 | >2000 | >2000 | 119.4 |
*
IC50 values were calculated 24 h post-treatment.