Table 3.
Nuclear magnetic resonance spectral analysis of GlycA and lipoprotein particles and size of the nine participants.
| Baseline | 12 weeks | Changes (12 weeks - baseline) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Median | P25 | P75 | Median | P25 | P75 | Median | P25 | P75 | p -value | |
| GlycA, μmol/L | 378.0 | 340.0 | 420.0 | 348.0 | 317.0 | 374.0 | −23.0 | −64.0 | −17.0 | 0.01 |
| VLDL and chylomicron | ||||||||||
| Total, nmol/L | 84.1 | 81.6 | 93.1 | 70.9 | 49.9 | 76.4 | −23.6 | −34.6 | 0.2 | 0.05 |
| Large, nmol/L | 4.0 | 3.3 | 8.0 | 3.0 | 2.4 | 5.1 | −0.4 | −3.3 | 0.1 | 0.20 |
| Medium, nmol/L | 33.5 | 21.2 | 47.1 | 21.8 | 15.1 | 28.1 | −4.6 | −19.6 | −1.8 | 0.10 |
| Small, nmol/L | 44.2 | 35.6 | 53.0 | 35.9 | 30.8 | 38.1 | −15.8 | −25.0 | 5.2 | 0.25 |
| IDL particles, nmol/L | 35.0 | 29.0 | 123.0 | 72.0 | 60.0 | 142.0 | 25.0 | 10.0 | 57.0 | 0.20 |
| LDL particles | ||||||||||
| Total, nmol/L | 1000.0 | 835.0 | 1337.0 | 822.0 | 799.0 | 1150.0 | −75.0 | −187.0 | −34.0 | 0.02 |
| Large, nmol/L | 322.0 | 163.0 | 508.0 | 100.0 | 17.0 | 239.0 | −153.0 | −222.0 | −131.0 | 0.01 |
| Small, nmol/L | 765.0 | 509.0 | 849.0 | 709.0 | 641.0 | 812.0 | 14.0 | −87.0 | 47.0 | 0.89 |
| HDL particles | ||||||||||
| Total, μmol/L | 33.7 | 30.6 | 35.3 | 34.0 | 30.8 | 34.8 | 0.5 | −0.5 | 2.3 | 0.74 |
| Large, μmol/L | 7.5 | 5.0 | 8.7 | 6.9 | 5.9 | 7.8 | 0.3 | −1.3 | 1.0 | 0.98 |
| Medium, μmol/L | 6.3 | 4.0 | 8.1 | 6.4 | 5.6 | 8.0 | 1.1 | −0.2 | 4.4 | 0.38 |
| Small, μmol/L | 22.1 | 15.8 | 23.5 | 19.4 | 14.2 | 22.5 | −1.1 | −4.3 | 1.6 | 0.50 |
| Size | ||||||||||
| VLDL, nm | 47.5 | 45.7 | 50.8 | 47.6 | 44.9 | 48.7 | −0.8 | −4.5 | 3.1 | 0.57 |
| LDL, nm | 20.2 | 20.2 | 20.7 | 20.0 | 19.8 | 20.2 | −0.3 | −0.4 | −0.2 | 0.94 |
| HDL, nm | 9.3 | 8.8 | 9.9 | 9.3 | 9.3 | 9.5 | 0.0 | −0.3 | 0.2 | 0.02 |
| Triglyceride, mg/dL* | 159.0 | 129.0 | 188.0 | 120.0 | 77.0 | 168.0 | −20.0 | −86.0 | −3.0 | 0.10 |
| VDLD and chylomicron TG, mg/dL* | 112.0 | 98.0 | 133.0 | 93.0 | 70.0 | 115.0 | −18.0 | −60.0 | −2.0 | 0.09 |
| HDL cholesterol, mg/dL* | 49.0 | 47.0 | 52.0 | 47.0 | 45.0 | 51.0 | −2.0 | −4.0 | 3.0 | 0.41 |
| Lipoprotein insulin resistance score | 48.0 | 41.0 | 56.0 | 40.0 | 38.0 | 55.0 | −4.0 | −5.0 | −1.0 | 0.18 |
SD, standard deviation; P25, 25th percentile; P75, 75th percentile; VLDL, very low density lipoprotein; IDL, intermediate density lipoprotein; LDL, low density lipoprotein; HDL, high density lipoprotein; TG, triglyceride.
*
Calculated values provided by LabCorp (Morrisville, NC, USA).