Table 4.
Nuclear magnetic resonance spectral analysis of GlycA and lipoprotein particles and size of the nine participants.
| Baseline | 12 weeks | Changes (12 weeks - baseline) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Median | P25 | P75 | Median | P25 | P75 | Median | P25 | P75 | p -value | |
| Weight, kg | 65.3 | 64.0 | 75.3 | 64.0 | 62.1 | 69.2 | −1.9 | −5.5 | 0.0 | 0.03 |
| BMI, kg/m2 | 27.9 | 26.0 | 29.4 | 27.0 | 24.9 | 27.9 | −0.7 | −2.2 | 0.0 | 0.03 |
| Waist, cm | 90.0 | 83.0 | 94.5 | 87.0 | 82.0 | 89.0 | −2.0 | −5.0 | −1.0 | <0.01 |
| Hemoglobin | 13.8 | 13.4 | 14.2 | 13.7 | 12.9 | 14.0 | 0.0 | −0.5 | 0.1 | 0.33 |
| Triglyceride (TG), mg/dL | 139.0 | 96.0 | 186.0 | 138.0 | 103.0 | 166.0 | −5.0 | −37.0 | 9.0 | 0.36 |
| Total cholesterol (TC), mg/dL | 189.0 | 181.0 | 217.0 | 164.0 | 143.0 | 179.0 | −22.0 | −31.0 | −18.0 | <0.01 |
| High-density lipoprotein (HDL-c), mg/dL | 46.0 | 44.0 | 55.0 | 45.0 | 42.0 | 48.0 | −6.0 | −7.0 | 0.0 | 0.06 |
| Low-density lipoprotein (LDL-c), mg/dL | 112.0 | 99.0 | 153.0 | 90.0 | 77.0 | 119.0 | −24.0 | −27.0 | −17.0 | 0.04 |
| LDL/HDL ratio | 1.8 | 1.8 | 3.1 | 2.0 | 1.6 | 2.8 | −0.3 | −0.3 | −0.1 | |
| Oxdized LDL, μg/dL | 56.1 | 54.9 | 69.0 | 54.1 | 47.7 | 59.6 | −2.2 | −8.4 | −1.5 | 0.13 |
| Glucose, mg/dL | 100.0 | 95.0 | 106.0 | 102.0 | 92.0 | 106.0 | 0.0 | −4.0 | 4.0 | 0.98 |
| HbA1c, % | 6.0 | 5.8 | 6.3 | 5.7 | 5.6 | 5.9 | −0.2 | −0.4 | −0.1 | 0.02 |
| Insulin, μU/mL | 11.1 | 10.3 | 14.2 | 7.1 | 5.6 | 12.2 | −3.2 | −4.8 | −2.0 | 0.07 |
| HOMA IR | 3.2 | 2.2 | 3.7 | 1.8 | 1.4 | 3.2 | −0.7 | −0.8 | −0.6 | 0.04 |
| HOMA Beta | 116.4 | 67.6 | 126.2 | 79.0 | 52.0 | 107.9 | −33.3 | −68.3 | −5.0 | 0.10 |
| hs-CRP, mg/dL | 0.1 | 0.0 | 0.2 | 0.0 | 0.0 | 0.0 | 0.0 | −0.1 | 0.0 | 0.25 |
| TMAO, μM | 3.1 | 110.3 | 630.5 | 2.4 | 132.8 | 286.5 | −0.2 | −262.2 | 67.1 | 0.50 |
| Choline, μM | 10.2 | 872.5 | 1217.8 | 7.4 | 645.6 | 896.0 | −1.8 | −495.0 | −79.1 | 0.05 |
| Carnitine, μM | 25.9 | 3934.3 | 4699.4 | 26.0 | 3969.2 | 4761.2 | 0.4 | −145.4 | 231.9 | 0.91 |
| Holotranscobalamin, pmol/L | 77.0 | 57.2 | 128.0 | 89.9 | 82.8 | 143.1 | 7.6 | −17.4 | 25.5 | 0.57 |
SD, standard deviation; P25, 25th percentile; P75, 75th percentile; BMI, body mass index; TG, triglyceride; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; HbA1c, glycated hemoglobin; HOMA-IR, homeostatic model assessment for insulin resistance; HOMA-Beta, homeostatic model assessment for beta cell function; hs-CRP, high-sensitivity C-reactive protein; TMAO, trimethylamine N-Oxide.