Evaluation of green chemistry metrics for the synthesis of 2a.
| Reactant | 1a | 1.3 g | 5 mmol | FW 273.38 |
| Acid | AcOH | 1.5 g | 25 mmol | FW 60.05 |
| Solvent | Acetone | 25.51 | — | — |
| Recycled solvent | Acetone | 15.75 | — | — |
| Product | 2a | 0.97 g | 3.22 mmol | FW 301.35 |
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