Table 1. Baseline clinicopathological characteristics.
| Factors | All | SII | PALBI | |||||
|---|---|---|---|---|---|---|---|---|
| High | Low | P | High | Low | P | |||
| N | 214 | 57 | 157 | – | 159 | 55 | – | |
| Age (years), mean (±SD) | 60.29 (±9.353) | 0.107 | 0.340 | |||||
| Sex, n (%) | 0.976 | 0.005 | ||||||
| Male | 128 (59.8) | 34 | 94 | 104 | 24 | |||
| Female | 86 (40.2) | 23 | 63 | 55 | 31 | |||
| Jaundice, n (%) | 0.003 | <0.001 | ||||||
| Yes | 85 (39.7) | 32 | 53 | 85 | 0 | |||
| No | 129 (60.3) | 25 | 104 | 74 | 55 | |||
| CA19-9 (U/mL) | 0.917 | 0.053 | ||||||
| ≤114 | 78 (36.4) | 14 | 64 | 52 | 26 | |||
| >114 | 136 (63.6) | 43 | 93 | 107 | 29 | |||
| Alb (g/L) | <0.001 | 0.021 | ||||||
| ≥30 | 205 (95.8) | 50 | 155 | 55 | 150 | |||
| <30 | 9 (4.2) | 7 | 2 | 9 | 0 | |||
| TBIL (μmol/L) | <0.001 | <0.001 | ||||||
| 0–35 | 120 (56.1) | 19 | 101 | 65 | 55 | |||
| 36–200 | 44 (20.6) | 13 | 31 | 44 | 0 | |||
| >200 | 50 (23.4) | 25 | 25 | 50 | 0 | |||
| ALT (U/L) | 0.084 | <0.001 | ||||||
| 0–100 | 133 (62.1) | 30 | 103 | 79 | 54 | |||
| >100 | 81 (37.9) | 27 | 54 | 80 | 1 | |||
| AST (U/L) | 0.002 | <0.001 | ||||||
| 0–80 | 150 (70.1) | 31 | 119 | 95 | 55 | |||
| >80 | 64 (29.9) | 38 | 26 | 64 | 0 | |||
| CRP (mg/L) | 0.109 | 0.357 | ||||||
| ≤0.5 | 117 (54.7) | 26 | 91 | 84 | 33 | |||
| >0.5 | 97 (45.3) | 31 | 66 | 75 | 22 | |||
| Pancreatitis | 0.915 | 0.384 | ||||||
| Yes | 8 (3.7) | 2 | 6 | 7 | 1 | |||
| No | 206 (96.3) | 55 | 151 | 152 | 54 | |||
| Abdominal pain | 0.003 | 0.988 | ||||||
| Yes | 183 (85.5) | 42 | 141 | 136 | 47 | |||
| No | 31 (14.5) | 15 | 16 | 23 | 8 | |||
| Diabetes | 0.778 | 0.226 | ||||||
| Yes | 46 (21.5) | 13 | 33 | 31 | 15 | |||
| No | 168 (78.5) | 44 | 124 | 128 | 40 | |||
| Perineural invasion | 0.165 | 0.204 | ||||||
| Yes | 179 (83.6) | 128 | 51 | 43 | 136 | |||
| No | 35 (16.4) | 29 | 6 | 12 | 23 | |||
| Lymph node metastasis | 0.001 | 0.883 | ||||||
| Yes | 103 (48.1) | 65 | 38 | 26 | 77 | |||
| No | 111 (51.9) | 92 | 19 | 29 | 82 | |||
| Vascular invasion | 0.037 | 0.447 | ||||||
| Yes | 95 (44.4) | 63 | 32 | 22 | 73 | |||
| No | 119 (55.6) | 94 | 25 | 33 | 86 | |||
| Tumor location | 0.160 | <0.001 | ||||||
| Head | 140 (65.4) | 43 | 97 | 120 | 20 | |||
| Body | 54 (25.2) | 11 | 43 | 29 | 25 | |||
| Tail | 20 (9.3) | 3 | 17 | 10 | 10 | |||
| Tumor size | 0.614 | 0.054 | ||||||
| ≤2 cm | 27 (12.6) | 7 | 20 | 24 | 3 | |||
| ≤4 and >2 cm | 137 (64.0) | 34 | 103 | 103 | 34 | |||
| >4 cm | 50 (23.4) | 16 | 34 | 32 | 18 | |||
| Operative method | 0.012 | <0.001 | ||||||
| PPPD | 140 (65.4) | 53 | 87 | 120 | 20 | |||
| Distal pancreatectomy | 74 (34.6) | 15 | 59 | 39 | 35 | |||
P refers to the difference between the high and low groups. Alb, albumin; ALT, alanine transaminase; AST, aspartate transaminase CA19-9, carbohydrate antigen 19-9; CRP, C-reactive protein; PALBI grade, platelet-albumin-bilirubin grade; PPPD, pylorus-preserving pancreaticoduodenectomy; SD, standard deviation; SII, systemic immune-inflammation index; TBIL, total bilirubin.