Table 2. Univariate and multivariate cox proportional hazard regression analysis of OS.
Variables | Univariate analysis | Multivariate analysis | |||
---|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | ||
Sex | 1.089 (0.619–1.915) | 0.768 | 1.197 (0.590–2.427) | 0.618 | |
Jaundice (yes vs. no) | 1.711 (0.950–3.084) | 0.074 | 0.648 (0.156–2.695) | 0.551 | |
CA19-9 (≤114 vs. >114 U/mL) | 1.000 (0.999–1.001) | 0.809 | 0.822 (0.426–1.588) | 0.560 | |
Alb (≥30 vs. <30 g/L) | 3.601 (0.466–27.833) | 0.219 | 2.866 (0.276–29.724) | 0.378 | |
TBIL (μmol/L) | |||||
0–35 vs. 36–200 | 1.930 (0.988–3.770) | 0.054 | 2.653 (0.595–11.831) | 0.201 | |
0–35 vs. >200 | 1.855 (0.825–4.169) | 0.135 | 2.983 (0.611–14.574) | 0.177 | |
ALT (0–100 vs. >100 U/L) | 1.926 (1.072–3.458) | 0.028 | 1.304 (0.272–6.240) | 0.740 | |
AST (0–80 vs. >80 U/L) | 1.994 (1.078–3.687) | 0.028 | 1.149 (0.316–4.181) | 0.833 | |
PLT (109/L) (>300 vs. ≤300) | 2.312 (1.024–5.219) | 0.044 | NA | ||
Tumor location | |||||
Head vs. body | 1.155 (0.621–2.147) | 0.649 | 1.825 (0.369–9.021) | 0.461 | |
Head vs. tail | 0.447 (0.13–1.488) | 0.189 | 1.040 (0.161–6.704) | 0.967 | |
Tumor size (cm) | |||||
≤2 vs. ≤4 and >2 | 0.659 (0.301–1.442) | 0.297 | 0.513 (0.200–1.320) | 0.167 | |
≤2 vs. >4 | 0.276 (0.083–0.919) | 0.036 | 0.215 (0.055–0.834) | 0.026 | |
Operative method | 1.010 (0.560–1.820) | 0.974 | 1.365 (0.251–7.425) | 0.719 | |
Diabetes (yes vs. no) | 1.121 (0.591–2.126) | 0.727 | 0.818 (0.391–1.709) | 0.593 | |
Perineural invasion (yes vs. no) | 1.489 (0.753-2.941) | 0.252 | 1.046 (0.476–2.303) | 0.910 | |
Lymph node metastasis (yes vs. no) | 3.285 (1.652–6.530) | 0.001 | 2.874 (1.286–6.423) | 0.010 | |
Vascular invasion (yes vs. no) | 2.520 (1.377–4.614) | 0.003 | 2.502 (1.282–4.883) | 0.007 | |
SII (≥705 vs. <705) | 2.995 (1.658–5.412) | 0.000 | 2.843 (1.446–5.588) | 0.002 | |
PALBI grade (≥−5.6 vs. <−5.6) | 1.889 (0.937–3.808) | 0.075 | NA | ||
PLR (≤127 vs. >127) | 2.277 (1.224–4.236) | 0.009 | NA | ||
NLR (≤1.35 vs. >1.35) | 4.045 (1.246–13.133) | 0.020 | NA |
NA indicates not included in the multivariate analysis model due to interference of these indices with the SII. Alb, albumin; ALT, alanine transaminase; AST, aspartate transaminase; CA19-9, carbohydrate antigen 19-9; CI, confidence interval; HR, hazard ratio; NLR, neutrophil/lymphocyte ratio; OS, overall survival; PALBI grade, platelet-albumin-bilirubin grade; PLR, platelet/lymphocyte ratio; PLT, platelet; SII, systemic immune-inflammation index; TBIL, total bilirubin.