Table 3. Univariate and multivariate cox proportional hazard regression analysis of DFS.
| Variables | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Sex | 0.871 (0.543–1.396) | 0. 565 | 0.818 (0.482–1.390) | 0.458 | |
| Jaundice (yes vs. no) | 0.638 (0.395–1.030) | 0.066 | 0.595 (0.167–2.117) | 0.595 | |
| CA19-9 (≤114 vs. >114 U/mL) | 1.115 (0.697–1.782) | 0.650 | 0.790 (0.454–1.377) | 0.406 | |
| Alb (≥30 vs. <30 g/L) | 3.894 (0.540–28.098) | 0.178 | 3.527 (0.411–30.274) | 0.250 | |
| TBIL (μmol/L) | |||||
| 0–35 vs. 36–200 | 0.476 (0.252–0.900) | 0.022 | 0.295 (0.099–0.875) | 0.028 | |
| 0–35 vs. >200 | 0.661 (0.373–1.170) | 0.155 | 0.793 (0.227–2.774) | 0.716 | |
| ALT (0–100 vs. >100 U/L) | 0.661 (0.410–1.065) | 0.089 | 3.227 (0.994–10.479) | 0.051 | |
| AST (0–80 vs. >80 U/L) | 0.616 (0.366–1.039) | 0.069 | 1.061 (0.421–2.673) | 0.900 | |
| PLT (109/L) (>300 vs. ≤300) | 0.563 (0.227–1.399) | 0.216 | NA | ||
| Tumor location | |||||
| Head vs. body | 1.564 (0.917–2.666) | 0.100 | 1.446 (0.314–6.659) | 0.636 | |
| Head vs. tail | 2.655 (1.384–5.093) | 0.003 | 1.922 (0.389–9.485) | 0.423 | |
| Tumor size (cm) | |||||
| ≤2 vs. ≤4 and >2 | 3.444 (1.242–9.552) | 0.018 | 2.442 (0.803–7.427) | 0.116 | |
| ≤2 vs. >4 | 5.973 (2.001–17.831) | 0.001 | 5.600 (1.571–19.960) | 0.008 | |
| Operative methods | 1.765 (1.042–2.990) | 0.034 | 1.148 (0.257–5.131) | 0.856 | |
| Diabetes (yes vs. no) | 1.985 (1.245–3.164) | 0.004 | 2.228 (1.182–4.199) | 0.013 | |
| Perineural invasion (yes vs. no) | 2.578 (1.320–5.038) | 0.006 | 3.925 (1.773–8.689) | 0.001 | |
| Lymph node metastasis (yes vs. no) | 2.345 (1.480–3.717) | 0.000 | 2.565 (1.453–4.526) | 0.001 | |
| Vascular invasion (yes vs. no) | 1.085 (0.671–1.756) | 0.739 | 1.065 (0.606–1.870) | 0.828 | |
| SII (≥705 vs. <705) | 0.550 (0.307–0.987) | 0.045 | 0.235 (0.110–0.502) | 0.000 | |
| PALBI (≥−5.6 vs. <−5.6) | 0.727 (0.430–1.231) | 0.235 | NA | ||
| PLR (≤127 vs. >127) | 0.517 (0.324–0.825) | 0.006 | NA | ||
| NLR (≤1.35 vs. >1.35) | 0.741 (0.375–1.448) | 0.380 | NA | ||
NA indicates not included in the multivariate analysis model due to interference of these indices with the SII. Alb, albumin; ALT, alanine transaminase; AST, aspartate transaminase; CA19-9, carbohydrate antigen 19-9; CI, confidence interval; DFS, disease-free survival; HR, hazard ratio; NLR, neutrophil/lymphocyte ratio; PALBI grade, platelet-albumin-bilirubin grade; PLR, platelet/lymphocyte ratio; PLT, platelet; SII, systemic immune-inflammation index; TBIL, total bilirubin.