Table 2. Univariate and multivariate Cox analysis of OS and CSS.
| Variables | OS | CSS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | ||||
| Age (years) | 1.09 (1.08, 1.10) | <0.001 | 1.08 (1.07, 1.09) | <0.001 | 1.07 (1.05, 1.08) | <0.001 | 1.04 (1.02, 1.05) | <0.001 | |||
| Sex | |||||||||||
| Female | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | |||||||
| Male | 1.86 (1.56, 2.21) | <0.001 | 1.27 (1.06, 1.53) | 0.011 | 1.73 (1.24, 2.42) | 0.001 | 0.86 (0.61, 1.23) | 0.409 | |||
| Race | |||||||||||
| Black | 1 (ref) | 1 (ref) | |||||||||
| White | 0.97 (0.71, 1.32) | 0.822 | 1.69 (0.79, 3.62) | 0.178 | |||||||
| Other | 0.78 (0.48, 1.26) | 0.305 | 2.17 (0.86, 5.52) | 0.103 | |||||||
| Summary stage | |||||||||||
| Distant | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | |||||||
| Localized | 0.11 (0.08, 0.14) | <0.001 | 0.46 (0.24, 0.85) | 0.014 | 0.02 (0.01, 0.03) | <0.001 | 0.31 (0.13, 0.78) | 0.012 | |||
| Regional | 0.24 (0.18, 0.32) | <0.001 | 0.62 (0.36, 1.08) | 0.091 | 0.14 (0.09, 0.21) | <0.001 | 0.64 (0.31, 1.29) | 0.207 | |||
| Tumor size (mm) | 1.01 (1.01, 1.01) | <0.001 | 1.01 (1.00, 1.01) | <0.001 | 1.01 (1.01, 1.01) | <0.001 | 1.01 (1.01, 1.02) | <0.001 | |||
| T stage | |||||||||||
| T1 | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | |||||||
| T2 | 1.21 (0.93, 1.59) | 0.162 | 0.82 (0.44, 1.54) | 0.536 | 1.07 (0.48, 2.38) | 0.872 | 0.87 (0.32, 2.37) | 0.780 | |||
| T3 | 2.13 (1.65, 2.75) | <0.001 | 1.25 (0.70, 2.24) | 0.452 | 5.54 (2.85, 10.76) | <0.001 | 1.58 (0.63, 3.94) | 0.325 | |||
| T4 | 7.42 (5.41, 10.16) | <0.001 | 1.77 (0.95, 3.33) | 0.074 | 38.97 (19.71, 77.06) | <0.001 | 1.96 (0.78, 4.96) | 0.153 | |||
| N stage | |||||||||||
| N0 | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | |||||||
| N1 | 3.45 (2.67, 4.48) | <0.001 | 1.71 (1.22, 2.39) | 0.002 | 10.52 (7.37, 15.00) | <0.001 | 1.73 (1.12, 2.66) | 0.013 | |||
| M stage | |||||||||||
| M0 | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | |||||||
| M1 | 9.90 (7.50, 13.07) | <0.001 | 2.03 (1.19, 3.49) | 0.009 | 34.36 (23.87, 49.46) | <0.001 | 2.80 (1.44, 5.47) | 0.003 | |||
| AJCC stage | |||||||||||
| I | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | |||||||
| II | 2.40 (1.83, 3.16) | <0.001 | 1.39 (0.73, 2.63) | 0.313 | 1.39 (0.54, 3.60) | 0.498 | 0.97 (0.29, 3.30) | 0.965 | |||
| III | 3.51 (2.71, 4.55) | <0.001 | 0.76 (0.43, 1.34) | 0.34 | 7.72 (3.76, 15.86) | <0.001 | 1.93 (0.73, 5.10) | 0.183 | |||
| IV | 13.22 (9.99, 17.49) | <0.001 | 0.81 (0.41, 1.59) | 0.535 | 82.40 (41.34, 164.27) | <0.001 | 4.74 (1.57, 14.32) | 0.006 | |||
| Thyroidectomy | 0.10 (0.06, 0.16) | <0.001 | 0.29 (0.18, 0.49) | <0.001 | 0.06 (0.03, 0.10) | <0.001 | 0.30 (0.15, 0.60) | <0.001 | |||
OS, overall survival; CSS, cancer-specific survival; HR, hazard ratio; AJCC, American Joint Committee on Cancer.