Table 3.
Cox proportional hazard regression analysis for hazard of death at 5 years among patients with overall advanced stage (Stage III/IV) disease. Patients in each age cohort who received surgery and adjuvant radiation therapy had improved survival at 5 years when compared to single modality therapy across all age groups, even when controlling for insurance, comorbidity, site, race, and overall stage. Comorbidity was independently associated with increased risk of 5-year mortality across all age cohorts.
| Stage III/IV (Advanced Stage) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 40–59 yrs | 60–69 yrs | 70–79 yrs | 80+ yrs | ||||||
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | ||
| Insurance | Uninsured | Ref | Ref | Ref | Ref | ||||
| Private | 0.74 (0.65, 0.85) | <0.001 | 0.89 (0.71, 1.12) | 0.328 | 0.76 (0.45, 1.29) | 0.313 | 1.65 (0.52, 5.21) | 0.395 | |
| Medicaid | 1.19 (1.03, 1.37) | 0.021 | 1.31 (1.02, 1.69) | 0.036 | 0.77 (0.41, 1.45) | 0.423 | 1.63 (0.47, 5.67) | 0.439 | |
| Medicare | 1.1 (0.93, 1.31) | 0.253 | 1.12 (0.9, 1.39) | 0.322 | 0.89 (0.54, 1.48) | 0.661 | 1.82 (0.58, 5.66) | 0.304 | |
| Other government | 0.93 (0.69, 1.25) | 0.620 | 1.07 (0.77, 1.5) | 0.678 | 0.75 (0.37, 1.54) | 0.436 | 4.25 (1.16, 15.53) | 0.029 | |
| Treatment | Surgery Alone | Ref | Ref | Ref | Ref | ||||
| Surgery/Radiation | 0.72 (0.65, 0.81) | <0.001 | 0.66 (0.59, 0.75) | <0.001 | 0.62 (0.54, 0.7) | <0.001 | 0.64 (0.56, 0.75) | <0.001 | |
| Triple Modality | 0.95 (0.86, 1.04) | 0.281 | 0.82 (0.74, 0.92) | <0.001 | 0.78 (0.68, 0.89) | <0.001 | 0.75 (0.56, 0.99) | 0.045 | |
| Comorbidity | 0 | Ref | Ref | Ref | Ref | ||||
| 1 | 1.13 (1.02, 1.26) | 0.023 | 1.22 (1.09, 1.35) | <0.001 | 1.18 (1.05, 1.33) | 0.005 | 1.23 (1.07, 1.43) | 0.005 | |
| 2+ | 1.51 (1.27, 1.8) | <0.001 | 1.37 (1.17, 1.61) | <0.001 | 1.45 (1.23, 1.72) | <0.001 | 1.51 (1.24, 1.83) | <0.001 | |
| Race | White | Ref | Ref | Ref | Ref | ||||
| Black | 0.96 (0.85, 1.1) | 0.585 | 1.24 (1.06, 1.45) | 0.007 | 1.3 (1.06, 1.61) | 0.012 | 0.97 (0.7, 1.34) | 0.835 | |
| Hispanic | 0.82 (0.67, 1) | 0.052 | 1.03 (0.82, 1.31) | 0.783 | 1.03 (0.8, 1.33) | 0.799 | 1.14 (0.85, 1.54) | 0.369 | |
| Other | 0.85 (0.67, 1.06) | 0.150 | 1.07 (0.82, 1.38) | 0.628 | 1.02 (0.77, 1.35) | 0.877 | 1.04 (0.68, 1.6) | 0.858 | |
| Overall Stage | I | -- | -- | -- | -- | ||||
| II | -- | -- | -- | -- | |||||
| III | Ref | Ref | Ref | Ref | |||||
| IV | 1.75 (1.58, 1.95) | <0.001 | 1.68 (1.5, 1.88) | <0.001 | 1.47 (1.3, 1.66) | <0.001 | 1.24 (1.08, 1.43) | 0.003 | |