| Methods |
Randomised, open, parallel study over a 24‐month study period |
| Participants |
Patients of both sexes, aged 6 to 65 years with partial or generalised epilepsy
The median number of seizures was 3 during 4 months before intervention |
| Interventions |
Monotherapy with carbamazepine, phenytoin, valproate, phenobarbital or primidone guided by therapeutic drug monitoring versus without support of drug level monitoring |
| Outcomes |
Proportion achieving seizure remission in the last 12 months
Proportion remaining seizure free since initiation of treatment
Proportion with side effects at any time |
| Notes |
Under powered
Not possible to evaluate individual drugs |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Low risk |
A ‐ Adequate |
