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. 2022 Mar 21;12(14):8815–8832. doi: 10.1039/d1ra08771a

Selected functionalized bakuchiol analogues and its functionalization sites and its up-regulated activity.

S. no. Selected modified analogues Functionality and modified site Up-regulated activity Reference
1 graphic file with name d1ra08771a-u11.jpg O-Methylation at phenolic –OH (site-I) and aryl group introduced at ethenyl group (site-III) Anti-proliferative activity 41
2 graphic file with name d1ra08771a-u12.jpg [1,3] oxazine ring introduced at phenolic –OH and phenolic o-CH (site-I) Anti-proliferative activity 44
3 graphic file with name d1ra08771a-u13.jpg Cationic group introduced at phenolic –OH (site-I) Anti-microbial activity 46
4 graphic file with name d1ra08771a-u14.jpg Electron withdrawing gp introduced at C(3) position (site-I) Anti-proliferative activity 42
5 graphic file with name d1ra08771a-u15.jpg Pyridine substituted piperazine moiety introduced at C(3) position (site-I) Anti-proliferative activity 45
6 graphic file with name d1ra08771a-u16.jpg Hydroxylation at C(13) position (site-II) Anti-proliferation activity 43
7 graphic file with name d1ra08771a-u17.jpg Aryl group introduced at ethenyl group (site-III) Anti-microbial activity 41