DIT synthesis by SMCCRa with various inorganic bases.
Entry | Base | Mono-substituted intermediate | DIT yield (η%) |
---|---|---|---|
1 | Cs2CO3 | Present | 89 |
2 | NaHCO3 | Present | 78 |
3 | KHCO3 | Present | 82 |
4 | NaOH | Absent | 88 |
5 | KOH | Absent | 91 |
Reaction conditions: 2,5-dibromothiophene 0.2 M; solvent mixture 1,4-dioxane/H2O (2 : 1); boronic ester 1.5 eq.; Pd(PPh3)4, catalyst 1.5 mol%; base 4 eq.; temperature 90 °C; time 24 h; argon atmosphere.