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. 2022 Mar 22;12(15):8924–8935. doi: 10.1039/d2ra00654e

DIT synthesis by SMCCRa with various inorganic bases.

Entry Base Mono-substituted intermediate DIT yield (η%)
1 Cs2CO3 Present 89
2 NaHCO3 Present 78
3 KHCO3 Present 82
4 NaOH Absent 88
5 KOH Absent 91
a

Reaction conditions: 2,5-dibromothiophene 0.2 M; solvent mixture 1,4-dioxane/H2O (2 : 1); boronic ester 1.5 eq.; Pd(PPh3)4, catalyst 1.5 mol%; base 4 eq.; temperature 90 °C; time 24 h; argon atmosphere.