TABLE 3.
ED50s for pneumococci in different multidosing regimensa
| Drug | ED50, mg/kg (95% CI; no. of mice), after the following no. of doses
|
|||||
|---|---|---|---|---|---|---|
| 1b | 2 | 4 | 8 | 12 | 24 | |
| Vancomycin | 0.65 (0.62–0.69; 85) | 0.82 (0.82–0.82; 50) | 1.27c (60) | 1.25c (60) | 6.00 (4.49–8.01; 70) | 6.79 (4.99–9.24; 70) |
| Teicoplanin | 0.45 (0.45–0.46; 115) | 0.83 (0.31–2.21; 50) | 1.22c (60) | 1.75 (0.51–6.02; 60) | 3.13 (2.19–4.47; 70) | 5.67 (4.94–6.50; 70) |
a
The treatments were given for 48 h starting 1 h after challenges. Mice were observed for 6 days.
b
Same data as in Table 1.
c
Not possible to calculate a 95% confidence interval (CI), but in all cases, R2 was >0.99 for goodness of fit.