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Correlations between various PK/PD parameters and effect in the multidosing trial, as determined with the Spearman rank correlation test
| Drug(s) | No. of regimens | Parameter selected | Spearman rhoa |
|---|---|---|---|
| Vancomycin | 39 | T>MIC-free | 0.78 |
| Cmax-free/MIC | 0.79 | ||
| AUC/MIC | 0.83 | ||
| Teicoplanin | 40 | T>MIC-free | 0.83 |
| Cmax-free/MIC | 0.85 | ||
| AUC/MIC | 0.77 | ||
| Vancomycin and teicoplanin | 79 | T>MIC-free | 0.82 |
| Cmax-free/MIC | 0.80 | ||
| AUC/MIC | 0.75 |
In all instances, P was <0.001.
