TABLE 5.
Correlations between various PK/PD parameters and effect in the multidosing trial, as determined by logistic regression
| Drug | Logistic regression analysis parameter | Gain in 2log(likelihood)a |
|---|---|---|
| Vancomycin | Intercept only | 0 |
| Log10(Cmax-free/MIC) | 184 | |
| Log10(AUC/MIC) | 218 | |
| Log10(Cmax-free/MIC) and log10(AUC/MIC) | 270 | |
| Log10(Cmax-free/MIC) and log10(AUC/MIC) and log10(T>MIC-free) | 271 | |
| Teicoplanin | Intercept only | 0 |
| Log10(Cmax-free/MIC) | 357 | |
| Log10(T>MIC-free) | 318 | |
| Log10(Cmax-free/MIC) and log10(T>MIC-free) | 375 | |
| Log10(Cmax-free/MIC) and log10(T>MIC-free) and log10(AUC/MIC) | 375 |
a
An arbitrary distance between covariates in the description of survival in experimental groups. The coviates are here the PK/PD parameters.