TABLE 6.
Comparable treatment regimens carried out with the mouse peritonitis model with S. pneumoniae and subcutaneous or intraperitoneal vancomycin and teicoplanin
| 48-h treatment regimens
|
No. of surviving mice/total no. of mice tested (%) with:
|
||||
|---|---|---|---|---|---|
| Vancomycin
|
Teicoplanin
|
||||
| Dosing interval (h) | Total dose (mg/kg) | Subcutaneous | Intraperitoneal | Subcutaneous | Intraperitoneal |
| 4 | 20 | 4/5 (80) | 5/5 (100) | 5/5 (100) | 3/5 (60) |
| 10 | 13/15 (86.6) | 5/5 (100) | 14/15 (93.3) | 5/5 (100) | |
| 5 | 1/5 (20) | 5/5 (100) | 5/5 (100) | 4/5 (80) | |
| 1 | 3/15 (20) | 2/5 (40) | 0/15 (0) | 2/5 (40) | |
| 2 | 20 | 5/5 (100) | 5/5 (100) | 4/5 (80) | 5/5 (100) |
| 10 | 9/15 (60) | 4/5 (80) | 15/15 (100) | 4/5 (80) | |
| 5 | 2/5 (40) | 2/5 (40) | 1/5 (20) | 5/5 (100) | |
| 1 | 2/15 (13.3) | 1/5 (20) | 1/15 (6.7) | 2/5 (40) | |