Gajdos 1983.
| Methods | RCT | |
| Participants | 14 participants with myasthenia gravis | |
| Interventions | Group 1: prednisone Group 2: prednisone and plasma exchange | |
| Outcomes | End points: muscle score, relapses, prednisone dose mean (SD) | |
| Notes | RCT aimed at comparing the long‐term effect of two therapeutic regimens, namely: prednisone (Group I) versus prednisone and plasma exchange (Group II) for chronic stable myasthenia gravis | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Adequate sequence generation? | Unclear risk | Information is lost but it was probably a computer random number generator (personal communication) |
| Allocation concealment? | Low risk | Sequentially numbered, opaque, sealed envelopes |
| Blinding? All outcomes | High risk | No blinding |
| Incomplete outcome data addressed? All outcomes | Low risk | No missing data at one month. Only one participant missing at one year |
| Free of selective reporting? | Low risk | The published report included all outcomes pre‐specified in the protocol |
| Free of other bias? | High risk | Imbalances between groups (gender and age). See text |