Table 1. Composition of Hydrogenated (h-LNCs) and Deuterated (d-LNCs) LNCs.
excipient | composition of h-LNCs (% w/v) | composition of d-LNCs (% w/v) |
---|---|---|
Labrafac lipophile WL 1349 | 6.2 | 5.89 |
octanoic-d15 acid (dC8) | 0.17 | |
decanoic-d19 acid (dC10) | 0.14 | |
Kolliphor HS 15 | 4.8 | 4.8 |
Phospholipon 90 H | 0.4 | 0.4 |
sodium chloride | 0.5 | 0.5 |
Milli-Q water/deuterium oxide (D2O) | q.s. | q.s. |
DF003a | 0.19 | 0.19 |
DF003 is only present in drug-loaded LNCs.