Extended Data Fig. 5 |. Genomic Variant Heatmap.

Heatmap of genotype (GT) of variant alleles on chromosome 1, across all human replicates across within sequencing platforms, as measured against the Genome in a Bottle high confidence variant call sets for each genome. Heterozygous variant alleles are shaded in orange (0.5), homozygous variants in red (1), missing data in blue (0), and inapplicable sites (sites outside of the GIAB high confidence region in one cell line but present in another) in gray. Hierarchical clustering reveals strong grouping by cell line, followed by less clear grouping within platforms and inter- and intra-lab replicates.