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. Author manuscript; available in PMC: 2022 Apr 6.
Published in final edited form as: Science. 2021 Oct 29;374(6567):eabb3420. doi: 10.1126/science.abb3420

Fig. 4. Hepatocytes under surveillance die upon macrophage differentiation and lymphocyte recruitment.

Fig. 4.

(A) Representative image and quantification of Tom+ hepatocytes associated with ≥1 B220+ cells. (B) Representative picture and quantification of Tom+ hepatocytes associated with ≥1 CD3ε+ cells. (C) Proportion of Tom+ and healthy (not dying) hepatocytes. (D) Representative picture and quantification of dying Tom+ hepatocytes. (E) Representative picture and quantification of Tom+ hepatocytes associated with ≥1 iNOS+ cells. (F) Quantitation of dying p21-OE Tom+ hepatocytes associated with ≥1 iNOS+ cells. Scale bars: 10 μm (A, B, D, and E). Mice used were on a C57BL/6×129Sv mixed genetic background. Data represent means ± SEM. Experiments in the above panels were performed once. ns, not significant. **P<0.01; ***P<0.001. One-way ANOVA with Sidak’s correction (A to E).