Table 2. Predicted Abilities of the Monomers toward Gut Absorption, Act as a BBB Permeant or P-gp Substrate, and the Various Molecular Targets It Can Bind^a.

monomer abbreviation	gut absorption	BBB permeant	P-gp substrate	molecular targets
OZ	high	yes	no	oxidoreductase, GPCR, hydrolase
AA	high	yes	no	oxidoreductase, protease
VP	high	yes	no	oxidoreductase, protease, hydrolase
Gly	high	no	no	dioxygenase, hydrolase
AcM	high	yes	no	protease, CYP450, kinase
DMA	high	yes	no	oxidoreductase, GPCR
HPMA	high	yes	no	transporter proteins, GPCR, CYP450, kinase
HEMA	high	yes	no	CYP450, GPCR, kinase
SA	low	no	yes	cytosolic proteins, kinase, voltage-gated ion channel
CBAA	high	no	no	membrane and nuclear receptors, GPCR, transcription factor, phosphodiesterase, phosphatase
CBMA	high	no	yes	oxidoreductase, GPCR, nuclear factors, secreted proteins, phosphatase, protease
SBMA	high	no	yes	GPCR, protease, kinase, voltage-gated ion channel, nuclear receptor, phosphatase
MPC	high	no	yes	oxidoreductase, protease, GPCR, kinase, CYP450, voltage-gated ion channel
VPPS	high	yes	no	CYP450, protease, kinase

^aAbbreviations: CYP, cytochrome P; GPCR, G-protein-coupled receptor.