TABLE 1.
Genes responding in five or more treatments
| Biological rolea | No. of genesb | No. of hitsc | Hit/gene ratio | No. of drug hitsd | Drug hit/ gene ratio | No. of KO hitse | KO hit/ gene ratio | No. (%) of genes responding to saturated culture | % of genes responding to:
|
Direction of changef | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug treatment | KO | ||||||||||
| Unknownfg | |||||||||||
| Up | 26 | 154 | 5.92 | 124 | 4.77 | 30 | 1.15 | 0 (0) | 80 | 20 | Up |
| Up/sat'd | 8 | 52 | 6.50 | 35 | 4.38 | 17 | 2.13 | 8 (100) | 67 | 33 | Up |
| Down | 11 | 67 | 6.09 | 56 | 5.09 | 11 | 1.00 | 0 (0) | 84 | 16 | Down |
| Down/sat'd | 8 | 50 | 6.25 | 41 | 5.13 | 9 | 1.13 | 8 (100) | 82 | 18 | Down |
| Mitochondrial | 32 | 194 | 6.06 | 145 | 4.53 | 49 | 1.53 | 23 (72) | 75 | 25 | Up |
| 4 | 25 | 6.25 | 20 | 5.00 | 5 | 1.25 | 1 (25) | 80 | 20 | Down | |
| Lipid/fatty acid/sterol | 16 | 101 | 6.31 | 63 | 3.94 | 38 | 2.38 | 1 (6) | 62 | 38 | Up |
| 6 | 37 | 6.16 | 28 | 4.67 | 9 | 1.50 | 2 (33) | 76 | 24 | Down | |
| Protein synthesis and processing | 15 | 90 | 6.00 | 73 | 4.87 | 17 | 1.13 | 0 (0) | 81 | 19 | Up |
| 9 | 54 | 6.00 | 42 | 4.67 | 12 | 1.33 | 6 (67) | 78 | 22 | Down | |
| Stress | 15 | 90 | 6.00 | 59 | 3.93 | 31 | 2.07 | 5 (33) | 66 | 34 | Up |
| 5 | 31 | 6.20 | 25 | 5.00 | 6 | 1.20 | 4 (80) | 81 | 19 | Down | |
| Membrane associated | 8 | 45 | 5.62 | 39 | 4.88 | 6 | 0.75 | 0 (0) | 87 | 13 | Up |
| 8 | 50 | 6.25 | 36 | 4.50 | 14 | 1.75 | 3 (38) | 72 | 28 | Down | |
| Amino acid biosynthesis | 9 | 58 | 6.44 | 43 | 4.78 | 15 | 1.67 | 7 (78) | 74 | 26 | Up |
| Cell cycle control | 7 | 38 | 5.43 | 31 | 4.43 | 7 | 1.00 | 0 (0) | 82 | 18 | Up |
| Chromatin associated | 6 | 35 | 5.83 | 29 | 4.83 | 6 | 1.00 | 0 (0) | 83 | 17 | Up |
| Carbohydrate metabolism | 6 | 35 | 5.83 | 24 | 4.00 | 11 | 1.83 | 5 (83) | 69 | 31 | Up |
| Vesicle associated | 5 | 29 | 5.80 | 23 | 4.00 | 6 | 1.20 | 0 (0) | 79 | 21 | Down |
| Cell wall biosynthesis | 5 | 33 | 6.60 | 26 | 5.20 | 7 | 1.40 | 3 (60) | 79 | 21 | Up |
| Nucleotide metabolism | 5 | 28 | 5.60 | 19 | 3.80 | 9 | 1.80 | 3 (60) | 68 | 32 | Down |
| Other related genes | 4 | 24 | 6.00 | 19 | 4.75 | 5 | 1.25 | 1 (25) | 79 | 21 | Down |
| 3 | 17 | 5.67 | 11 | 3.67 | 6 | 2.00 | 1 (33) | 65 | 35 | Up | |
| Other genes | 12 | 66 | 5.50 | 58 | 4.83 | 8 | 0.67 | 2 (17) | 88 | 12 | Down |
a
Obtained from the YPD (18).
b
Number of responsive genes in each functional class.
c
No. of hits, number of total treatments in which the genes responded.
d
No. of drug hits, number of drug treatments in which the genes responded.
e
No. of KO hits, number of genetic disruptions (knockouts [KO]) to which the genes responded.
f
Up, increased transcript levels; down, decreased transcript levels.
g
Up/sat'd and Down/sat'd, increased and decreased transcript levels, respectively, in response to saturated culture.