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. 2022 Apr 5;24:25. doi: 10.1186/s13058-022-01514-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — ANXA1 expressed in 4T1 cells injected into the carotid artery may enhance initial tumor growth. a Diagram depicting model and cells injected into BALB/c mice. b Mice were injected with 4T1-luminescent cells into the intracarotid artery. Representative bioluminescence images and c violin plot quantification of brain metastases at Day-5 and Day-14 after intracarotid injection of 4T1-12b cells. d, e Representative bioluminescence images of the brains and violin plot quantification of brain metastases 14 days after intracarotid injection of 4T1-12B cells. f Weight loss and g Survival rates after injection of parental 4T1 or the ΔANXA1-4T1 tumor cells. h The ratio of CD45lo/CD11b+ Microglia in the brain at Day 14 analyzed by flow cytometry. i Expression of CD11b, CX3CR1, CD40, CD86 and CD206 in microglia. *P < 0.05, **P < 0.01, versus Sham, ^#P < 0.05 versus 4T1