Table 1.

Dose escalation and de-escalation boundaries (TTL = 0.3)

Design	Action	Num of patients treated at current dose
		3	6	9	12	15	18
mTPI	Escalate if Num of DLTs $\le$	0	1	1	2	2	3
	De-escalate if Num of DLTs $\ge$	2	3	4	5	7	8
Keyboard	Escalate if Num of DLTs $\le$	0	1	2	2	3	4
	De-escalate if Num of DLTs $\ge$	2	3	4	5	6	7
BOIN	Escalate if Num of DLTs $\le$	0	1	2	2	3	4
	De-escalate if Num of DLTs $\ge$	2	3	4	5	6	7