Table 1.

Inclusion and exclusion criteria used for study selection

Inclusion criteria	Exclusion criteria
Research involving the extraction, identification, or production of EVs or their contents, such as DNA, miRNA, or protein	Research involving nanoparticles but not extracellular vesicles from a cell source
Researching involving COPD, emphysema, bronchitis or any disease closely related to COPD in the respiratory tract	Research involving lung disease but not specifically COPD
Isolation method of EVs included	Research involving treatment but not pathogenesis or diagnosis of COPD
	Non-original research paper, e.g. reviews, commentary, case report, etc.
	Articles published in a language other than English