Fig. 6.

The effect of MMP408 on subretinal fibrosis. A Schematic view of the study design. Mice were treated with MMP408 (5 mg/kg twice daily, gavage) or vehicle three days after the second laser for 5 days. Eyes were collected on day 10 for immunohistochemistry. Subretinal fibrosis mice that received no treatment were considered as a treatment-naïve control group. B Representative confocal images of RPE/choroid flatmounts stained for collagen-1 from control non-treatment group, vehicle group and MMP408 group. Scale bar = 50 µm. C Quantitative analysis of collagen-1⁺ lesion area in different groups. Mean ± SD, n = 31–40 lesions per group from 8 to 10 eyes, *p < 0.05, **p < 0.01. One-way ANOVA followed by Tukey’s multiple comparison’s test