Table 6.

HR of resolution and incident NAFLD according to temporal PA change in BMI change ≤0 group

	Person-years	Events (No.)	Event rate (per 100,000 person-years)	Age- and sex-adjusted HR (95% CI)	Multivariable-adjusted HR (95% CI)
					Model 1	Model 2	Model 3
Resolution of NAFLD
Inactive→Inactive	9984.5	679	6.80	1.00	1.00	1.00	1.00
Active or HEPA→Inactive	6053.5	381	6.29	0.97 (0.86–1.10)	1.04 (0.92–1.18)	1.01 (0.89–1.15)	1.04 (0.92–1.18)
Inactive- → Active or HEPA	7373.8	502	6.80	1.05 (0.94–1.18)	1.05 (0.94–1.18)	1.08 (0.97–1.22)	1.00 (0.89–1.13)
Active or HEPA→Active or HEPA	12,075.7	877	7.26	1.21 (1.09–1.34)	1.26 (1.14–1.40)	1.24 (1.12–1.38)	1.18 (1.07–1.31)
Incident NAFLD
Inactive→Inactive	25,070.9	650	2.59	1.00	1.00	1.00	1.00
Active or HEPA→Inactive	14,209.1	452	3.18	1.04 (0.92–1.17)	1.02 (0.91–1.15)	1.02 (0.90–1.15)	1.00 (0.89–1.13)
Inactive- → Active or HEPA	14,575.9	450	3.08	1.03 (0.91–1.16)	1.03 (0.91–1.16)	0.94 (0.83–1.06)	0.99 (0.88–1.12)
Active or HEPA→Active or HEPA	25,353.3	860	3.39	0.92 (0.83–1.02)	0.90 (0.82–1.00)	0.89 (0.80–0.99)	0.93 (0.83–1.03)

Model 1: adjustment for age, sex, center, year of screening exam, smoking status, alcohol intake, education level

Model 2: model 1 adjustments plus adjustment for waist circumference

Model 3: model 2 adjustments plus adjustment for waist circumference changes

The reference group was persistently inactive group

Abbreviations: BMI Body mass index, CI Confidence interval, HEPA Health-enhancing physical activity, HR Hazard ratio, NAFLD Non-alcoholic fatty liver disease, PA Physical activity