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. 2022 Apr 6;120:1–11. doi: 10.1016/j.ijid.2022.04.006

Figure 2.

Figure 2

The protein expression of ACE2 and CD4 + T cell-related factors in patients with COVID-19 with and without diarrhea. The diarrhea group represented the COVID-19-diarrhea group, whereas the nondiarrhea group represented the COVID-19-nondiarrhea group. (a) The expression of ACE2 and CD4+ T cells related factors; (b-e) Statistics of ACE2 and related transcription factors (Tbet, GATA3, and RORc) expression; (f, g) Statistics of CD4+ T cells’ cytokines expression (TNFα, IL10). “HC” represented Healthy control. (one-way ANOVA test with Tukey post hoc test; n = 5 per group). Error bars denote the mean ± SEM. ns = not significant, *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001. ACE2 = angiotensin-converting enzyme 2; ANOVA = analysis of variance; GATA3 = GATA binding protein 3; IL = interleukin; RORc = retinoic acid receptor-related orphan receptor C; SEM = standard error of the mean; Tbet = T-box expressed in T cells; TNFα = tumor necrosis factor-alpha.