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. 2022 Apr 6;120:1–11. doi: 10.1016/j.ijid.2022.04.006

Figure 3.

Figure 3

Distribution of ACE2 and TNFα in colons of patients with COVID-19 with and without diarrhea. Representative fluorescence images (a) and quantification of optical density of ACE2 and TNFα (b). Panels from left to right: COVID-19-diarrhea (n = 6), COVID-19-nondiarrhea (n = 6), Crohn's disease (n = 8), ulcerative colitis (n = 8), and HC (n = 11). “HC” represented Healthy control. Scale bar corresponds to 50 μm. ACE2 (red), TNFα (green), and nucleus (DAPI; blue). (1-way ANOVA test with Bonferroni post hoc test; n = 6-11 per group) P < 0.05 was considered statistically significant. Error bars denote the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001. ACE2 = angiotensin-converting enzyme 2; ANOVA = analysis of variance; DAPI = 4′,6-diamidino-2-phenylindole; SEM = standard error of the mean; TNFα = tumor necrosis factor-alpha.