Figure 2.

Multimodal imaging in a 73-year-old patient suffering from a Cav (ID 11 in Table 1) with impaired NVC in a cortical area for language function (posterior superior temporal sulcus (STS) extending into Brodmann’s area 39). From left to right: BOLD fMRI-based cortical localizations superimposed onto axial T1w MRI data showed missing BOLD response when compared with MEG-based cortical localizations of language functions (482 ms poststimulus). MR imaging biomarker maps revealed alterations in oxygen metabolism (high CMRO₂ and low mitoPO₂) due to restrictions in cerebral blood volume (decreased CBV and µCBV) and microvascular architecture (decreased MVD and VSI) compared to the contralateral side to the lesion. Note: White lines indicate the slice intersections; black contour lines are the ROIs for data analysis; color coding bars are positioned on right-hand side of corresponding image. For the fMRI image, the color coding bar represents the correlation coefficient (r value).

fMRI: functional magnetic resonance imaging; MEG: magnetoencephalography; CMRO₂: cerebral metabolic rate of oxygen; mitoPO₂: mitochondrial oxygen tension; CBV: cerebral blood volume; µCBV: microvascular cerebral blood volume; MVD: microvessel density; VSI: vessel size index.