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. 2020 Aug 12;42(3):526–539. doi: 10.1177/0271678X20947546

Table 3.

Correlation coefficients between MR imaging biomarker values and BOLD fMRI metrics for all patients as well as for the patient subgroups with impaired and intact NVC.

All patients
Patients with impaired NVC
Patients with intact NVC
z score t score z score t score z score t score
OEF –0.770 –0.632 –0.581 –0.620 0.354 0.131
(%) (p < 0.001) (p = 0.003) (p = 0.171) (p = 0.138) (p = 0.235) (p = 0.670)
CMRO2 –0.136 0.068 0.094 0.166 0.280 0.474
(µmol/100g·min) (p = 0.569) (p = 0.777) (p = 0.840) (p = 0.722) (p = 0.354) (p = 0.102)
mitoPO2 0.802 0.619 –0.144 –0.185 0.038 –0.029
(mmHg) (p < 0.001) (p = 0.004) (p = 0.759) (p = 0.692) (p = 0.902) (p = 0.924)
CBV 0.683 0.538 –0.115 0.036 –0.144 –0.094
(%) (p = 0.001) (p = 0.014) (p = 0.806) (p = 0.938) (p = 0.638) (p = 0.761)
µCBV 0.564 0.616 –0.076 –0.125 –0.126 0.318
(%) (p = 0.010) (p = 0.004) (p = 0.871) (p = 0.789) (p = 0.682) (p = 0.290)
CBF 0.543 0.421 –0.199 –0.044 –0.397 –0.274
(ml/100g·min) (p = 0.013) (p = 0.065) (p = 0.669) (p = 0.925) (p = 0.179) (p = 0.365)
µCBF 0.696 0.578 –0.145 0.162 0.130 0.125
(ml/100g·min) (p = 0.001) (p = 0.008) (p = 0.757) (p = 0.729) (p = 0.671) (p = 0.683)
MVD 0.562 0.335 –0.124 0.036 0.078 –0.245
(mm–2) (p = 0.010) (p = 0.149) (p = 0.791) (p = 0.939) (p = 0.801) (p = 0.420)
VSI 0.485 0.401 –0.062 0.148 –0.132 –0.054
(µm) (p = 0.030) (p = 0.080) (p = 0.894) (p = 0.751) (p = 0.668) (p = 0.861)

OEF: oxygen extraction fraction; CMRO2: cerebral metabolic rate of oxygen; mitoPO2: mitochondrial oxygen tension; CBV: cerebral blood volume; µCBV: cerebral blood volume in microvasculature; CBF: cerebral blood flow; µCBF: cerebral blood flow in microvasculature; MVD: microvessel density; VSI: vessel size index.