Table 2.

Hemodynamic responses to the thigh-cuff test in normoxia and hypoxia after placebo and nitrate supplementation.

	Placebo		Nitrate		Two-way ANOVA
	Normoxia	Hypoxia	Normoxia	Hypoxia	Suppl.	Oxygen	Interaction
Thigh-cuff response
Max. ΔMAP (%)	−26.0 ± 4.1	−25.6 ± 4.6	−26.9 ± 3.8	−26.6 ± 3.8	0.525	0.683	0.913
Max. ΔICA flow (%)	−17.2 ± 2.3	−21.2 ± 4.7a	−17.9 ± 2.7	−21.8 ± 3.3a	0.557	<0.001	0.987
Dynamic CA variables (1–4 s after deflation)
Slope of CVC	0.041 ± 0.006	0.023 ± 0.008a	0.040 ± 0.011	0.026 ± 0.004a	0.646	<0.001	0.345
ΔMAP (%)	−17.0 ± 3.0	−16.7 ± 5.3	−17.9 ± 3.5	−17.1 ± 3.4	0.631	0.591	0.804

Note: Values are means  ±  SD.

^aIndicates significant difference between normoxia and hypoxia within the same supplementation.

MAP: mean arterial pressure; ICA: internal carotid artery; CVC: cerebrovascular conductance; Suppl.: supplementation.