TABLE 1.
Group designations and treatment regimen of 4-week gavage toxicity study with ICN 17261 and ribavirin in rats with 4-week recovery
| Group | Test material | No. of malesa | Dose level (mg/kg/day)b | Dose (mg/ml)b |
|---|---|---|---|---|
| 1 | Control | 12 | 0 | 0 |
| 2 | ICN 17261 | 12 | 60–300c | 6.0–30.0c |
| 3 | ICN 17261 | 12 | 180 | 18.0 |
| 4 | Ribavirin | 15 | 180 | 18.0 |
a
Four animals in each group designated as recovery animals were dosed daily for 29 days, after which dosing was discontinued, and the animals were observed for reversibility, persistence, or delayed occurrence of toxic effects for 31 days posttreatment.
b
The dose volume was 10 ml/kg.
c
On day 17, the dose level was increased to 300 mg/kg/day, and the dose concentration was increased to 30 mg/ml.