TABLE 3.

Four-week daily oral administration of ICN 17261 does not induce anemia or leukopenia in rats

Groupa	Test material	Dose (mg/ml/day)b	Level of:
			Hemoglobinc			Hematocritd			Leukocytee			Lymphocytef
			Day 11	Day 30	Day 60	Day 11	Day 30	Day 60	Day 11	Day 30	Day 60	Day 11	Day 30	Day 60
1	Control	0	14.1 ± 0.66	14.4 ± 0.61	15.1 ± 0.64	41.4 ± 2.08	42.6 ± 1.76	44.2 ± 1.78	7.5 ± 1.86	8.4 ± 2.65	11.8 ± 2.52	6.5 ± 1.73	7.1 ± 2.51	10.3 ± 2.64
2	ICN 17261	60–300	13.9 ± 0.63	14.4 ± 0.56	15.4 ± 0.37	40.7 ± 2.13	42.4 ± 1.26	45.1 ± 1.1	7.2 ± 0.83	9.0 ± 1.55	10.9 ± 1.26	6.1 ± 0.79	7.4 ± 1.26	9.0 ± 1.18
3	ICN 17261	180	14.0 ± 0.61	14.6 ± 0.54	15.5 ± 0.75	40.9 ± 2.01	42.9 ± 1.52	45.5 ± 2.97	6.8 ± 1.57	8.4 ± 1.88	9.6 ± 2.98	5.8 ± 1.31	6.8 ± 1.89	7.8 ± 2.81
4	Ribavirin	180	12.1 ± 1.01g	11.7 ± 1.54g	15.9 ± 0.45	32.9 ± 4.05g	31.7 ± 5.96g	45.3 ± 0.62	5.4 ± 1.41g	3.8 ± 1.10g	8.2 ± 2.79	4.8 ± 1.37g	2.8 ± 0.94g	6.8 ± 2.52

^aMeasurements at days 11 and 30 were from 12 male rats from each group except for group 4 (15 rats). Day 60 measurements were from four animals from each group designated as recovery animals which were dosed daily for 29 days, after which dosing was discontinued, and the animals were observed for reversibility, persistence, or delayed occurrence of toxic effects for 31 days posttreatment. 

^bDose regimen as in Table 1. 

^cHemoglobin values are shown as grams per deciliter. 

^dHematocrit values are shown as percentage of blood volume. 

^eLeukocyte count shown as cells × 10⁻³/μl. 

^fLymphocyte count shown as cells × 10⁻³/μl. 

^gGroup mean is significantly (P ≤ 0.05) different from mean of control group 1.