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. Author manuscript; available in PMC: 2022 Apr 6.
Published in final edited form as: Curr Opin Struct Biol. 2021 Jan 2;67:187–194. doi: 10.1016/j.sbi.2020.11.005

Figure 2.

Figure 2.

Druggable pockets in p53 DNA-binding domain. (a) L1/S3 pocket in an MD-generated open conformation [19], (b) Mutation-induced Y220C pocket from crystal structure (pdbID:3ZME, chain A), (c) L6 pocket in an MD-generated open conformation [8].