Table 2:
Selected examples and properties of therapeutics delivered with biomaterials to promote lymphangiogenesis
| Therapeutic | Biomaterial Carrier | Therapeutic Concentrations (μg/ml) |
Isoelectric Point |
Mass (kDa) |
Hydrodyanmic Radius (nm) [138] |
|---|---|---|---|---|---|
| ANG-2 | Hyaluran/ Methylcellulose | 1.0-3.0 [139] | 6.7 [140] | 1.0 | 0.7 |
| SDF-1α | PLGA | 0.4 [141] | 9.8 [142] | 7.0-8.0 | 1.5-1.6 |
| VEGF-C | Alginate | 0.5-2.0 [143] 7.5 x 103 [18] |
8.3 [144] | 15.5-21.0 | 2.0-2.3 |
| Fibrin/Collagen | 5.0-40.0 [145] | ||||
| Gelatin | 1.0 x 103 [146, 147] | ||||
| Hyaluran/ Methylcellulose | 0.2 [148] 1.0-3.0 [139] |
||||
| VEGF-D | Alginate | 0.5-2.0 [143] | 6.2 | 12.0-20.0 | 1.8-2.2 |