Table 3:

Selected examples of biomaterials designed to support lymphangiogenesis through promoting tissue ingrowth

Biomaterial Carrier	Targeted Cells	Predicted Biomaterial Mechanism	Intended Purpose	Reference
Collagen	LECs	Supports Sprout Ingrowth	Biological studies/Therapeutic screening	[169-172]
	LECs	Supports 3D microscale lymphatic vessels	Biological studies/Therapeutic screening	[173, 174]
	ECs	Interstitial flow through hydrogels	Biological studies	[175]
	LECs Caco-2	Supports coculture and interactions between both cell types	Biological studies/therapeutic screening of intestinal lymphatics	[176]
	LECs	PLGA nanofibers directed LEC migration	Directed lymphangiogenesis	[177]
	LECs	Promotes tissue regeneration and prevents scar formation	Topical dressing to promote lymphatic revascularization	[178, 179]
	LECs	Aligned nanofibers promotes LEC alignment/migration	Stimulate lymphatic regeneration	[180]
Fibrin	LECs	Supporting Sprout Ingrowth	Therapeutic screening	[143, 171, 181]
	ECs	Incorporates matrix bound VEGF and interstitial flow	Biological studies/Therapeutic screening	[182, 183]
	ECs	Varying hydrogel mechanical properties effect sprouting	Designing in vitro vascularized tissue	[184]
	ECs	Developing hydrogel channels to replicate lymphatic drainage	Designing engineered tissues	[185]
PLGA	LECs	Aligning polymers to direct LEC behavior	Repairing severed lymphatic vessels	[186]