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Mechanism of apoptotic induction of cancer cells by TNF-related apoptosis-inducing ligand. TRAIL actuate tumour cell death via acting as ligand for DR4 and DR5 that will trigger the initiator caspase-8 to promote apoptosis. Abbreviations: the TNF-related apoptosis-inducing ligand (TRAIL, cellular FLICE-inhibitory protein (cFLIP), death receptors 4 and 5 (DR4 and DR5), Bcl-2 homology 3 interacting-domain death agonist.
