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. Author manuscript; available in PMC: 2022 Apr 6.
Published in final edited form as: Hum Pathol. 2020 Sep 28;107:9–19. doi: 10.1016/j.humpath.2020.09.008
Univariate
Analysis
Multivariate Analysis
P HR (95% CI) P
Age 0.081 1.032 (1.011 – 1.053) 0.003
Gender 0.190
Tumor location 0.984
Adenoma-like adenocarcinoma 0.035
Tumor budding <0.001
Intraepithelial tumor infiltrating lymphocytes 0.002 0.010
 Yes 1
 No 2.332 (1.221 – 4.453)
Lymphovascular invasion <0.001
Perineural invasion 0.006
Tumor deposits <0.001
Stromal reaction <0.001 <0.001
 Immature/myxoid 3.085 (1.629 – 5.843)
 Intermediate 0.932 (0.466 – 1.864)
 Mature 1
MMR expression 0.744
pT-stage <0.001
pN-stage <0.001
pTNM prognostic stage group <0.001 <0.001
 I 0.118 (0.035 – 0.394)
 II 0.349 (0.196 – 0.622)
 III 1

Abbreviations: HR - Hazard ratio; CI - Confidence interval