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In vitro activity of GM 237354 against P. carinii. (A) Culture medium with 0.5 μg of GM 237354 per ml. A dramatic reduction in the number of microorganisms was observed. (B) Culture medium with 5 × 10−4 μg of GM 237354 per ml. A marked decrease in the number of microorganisms was observed. (C) Drug-free control culture. Trophozoites (open arrowhead) and trophozoite clusters (solid arrowhead) were observed. RAL-555 staining was used. Magnification, ×1,100.
