Table 3.

Risk factors for lymph node metastasis

	Univariable analysis			Multivariable analysis
	Odds ratio	95% CI	p value	Odds ratio	95% CI	p value
Age
≥40 years	Reference
<40 years	1.32	1.05~1.65	0.017	1.4	1.03~1.89	0.031
Gender
Male	Reference
Female	1.15	1.01~1.31	0.033	1.15	0.97~1.37	0.867
Tumor size
<2 cm	Reference
≥2 cm	10.19	7.89~13.18	<0.001	3.01	2.28~3.99	<0.001
pT-stage
T1	Reference
T2	6.02	4.90~7.40	<0.001	4.99	4.02~6.18	<0.001
T3	17.59	14.38~21.52	<0.001	13.42	10.85~16.61	<0.001
T4	73.51	53.18~101.60	<0.001	50.84	36.3~71.22	<0.001
Tumor location
Distal	Reference
Middle	1.14	0.98~1.34	0.087	0.79	0.65~0.97	0.024
Upper	1.91	1.62~2.24	<0.001	0.88	0.71~1.10	0.263
Diffuse	22.15	11.09~44.24	<0.001	2.01	0.90~4.47	0.089
Histology
Intestinal	Reference
Diffuse & mixed	2.06	1.81~2.33	<0.001	1.25	1.06~1.49	0.010