TABLE 3.

Multivariable models assessing the association of PNPLA3 genotype with advanced fibrosis

	Advanced fibrosis on MRE (≥3.63) OR (95% CI)	P-value
Model 1
CC (ref)	1
CG	3.120 (1.051–9.383)	0.0405
GG	7.380 (2.405–22.650)	0.0005
Model 2: Model 1 + BMI
CC (ref)	1
CG	3.154 (1.059–9.395)	0.0391
GG	6.829 (2.176–21.428)	0.0010
Model 3: Model 2 + FIB 4
CC (ref)	1
CG	2.417 (0.783–7.456)	0.1247
GG	5.257 (1.616–17.104)	0.0058
Model 4: Model 1 + DM
CC (ref)	1
CG	3.205 (1.068–9.614)	0.0377
GG	7.564 (2.452–23.334)	0.0004

Note: Model 1: Adjusted for age and sex.

Abbreviations: BMI, body mass index; DM, diabetes mellitus; FIB 4, fibrosis index based on the 4 factor; MRE, magnetic resonance elastography.