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. 2020 Mar 12;3(2):113–126. doi: 10.1093/pcmedi/pbaa009

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© The Author(s) 2020. Published by Oxford University Press on behalf of the West China School of Medicine & West China Hospital of Sichuan University.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — cep290 morphology (Mt) compared to wildtype (Wt) embryos. (A) Lateral and dorsal views of wholemount morphology in embryos at 24 hpf. Telencephalon (arrows) is projected forward in cep290 embryos. F, forebrain ventricle; M, midbrain ventricle. (B) Wildtype brain development at 48 hpf, 72 hpf, and 6 dpf. Left panels, wholemount morphology; right panels, transverse H and E sections through the midbrain. sb, swim bladder; mb, midbrain; onl, outer nuclear layer of the retina; inl, inner nuclear layer. Size bar = 100 μm. (C) cep290 brain development at 48 hpf, 72 hpf, and 6 dpf. Left panels, wholemount morphology; right panels, transverse H and E sections through the midbrain. h, hydrocephalus; nbl, neuroblastic layer; *periocular edema. Size bar = 100 μm.