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. 2020 Mar 12;3(2):113–126. doi: 10.1093/pcmedi/pbaa009

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© The Author(s) 2020. Published by Oxford University Press on behalf of the West China School of Medicine & West China Hospital of Sichuan University.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Ocular phenotype in cep290 mutants. (A) Wholemount TUNEL staining (green) comparing Wt eyes, untreated cep290 eyes (Mt), and eyes from Mt embryos treated with either 3 μM Ataluren (AT) or 3 μM AT plus 1 μM Amlexanox (AM). Sections were counterstained with DAPI. Size bar = 20 μm. (B) Visual background adaptation assay. In Wt embryos the melanophores (arrows) contract after 15 minutes of bright light, but not in cep290 embryos (Mt). Treatment with AT or AT/AM resulted in contracted melanophores in Mt embryos.