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Electrophysiological properties of NavSheP D60 mutants. (A and B) Time constants of activation (τm, A) and inactivation (τh, B) measured at −20mV for WT and D60E mutant. (C and D) Mid-points (V1/2) of activation (C) and inactivation (D) curves of NavSheP mutants exhibit different depolarization shifts relative to the V1/2 of the wild-type (WT) channel. Recordings were performed at 25°C (n=4–10).
