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. Author manuscript; available in PMC: 2022 Apr 6.
Published in final edited form as: Mov Disord. 2018 Nov 28;34(4):496–505. doi: 10.1002/mds.27558

FIG. 1.

FIG. 1.

Novel PD variants represented on LRRK2 quaternary structure: (a) overview of variants, represented as red spheres, on the structural model of dimeric LRRK2 (ref 27357661), represented as cartoon and surface. The following domain-specific color scheme is used: Armadillo in white, Ankyrin (ANK) in green, LRR in yellow, Roc in raspberry, COR in wheat, Kinase in slate, and WD40 in lime; (B) zoom of mutations affecting the Armadillo domain; (C) zoom of the mutation affecting the kinase domain. The ATP analogue, AppCp, fitted from the Roco4 Kinase domain (PDB ID: 4F0F), is shown as gray sticks; (D) sequence conservation logo of the G-loop region obtained from Pfam. Kinase family seed alignments and visualized with Jalview.