Table 2.
Diagnosis and demographic characteristics of true and false positives identified by the computable phenotype
| Characteristics | True Positives n=111 |
False Positives n=39 |
|---|---|---|
| Nephrologist-validated diagnosis, n (%) | ||
| MCD | 18 (16) | 0 |
| FSGS | 38 (34) | 0 |
| MN | 45 (41) | 0 |
| SSNS/SRNS | 4 (4) | 0 |
| Othera | 6 (5) | 0 |
| Secondary FSGS | 0 | 9 (23) |
| Lupus nephritis | 0 | 9 (23) |
| Diabetic kidney disease | 0 | 4 (10) |
| Focal global glomerulosclerosis | 0 | 2 (5) |
| Vasculitis | 0 | 2 (5) |
| Hypertensive nephrosclerosis | 0 | 1(3) |
| Other secondary causeb | 0 | 9 (23) |
| Unknown | 0 | 3 (8) |
| ESKD status, n (%) | ||
| Dialysis | 11 (10) | 4 (10) |
| Kidney transplant | 25 (23) | 8 (21) |
| Age, yr, mean (SD) | 43.3 (20.9) | 44.9 (19.2) |
| Nephrology encounter at site, n (%) | 110 (99) | 38 (97) |
| Time from nephrology encounter to computable phenotype capture, days, median (IQR) | 396 (0–1792) | 543 (16–2279) |
| Biopsy status, n (%) | N/A | |
| Documented and reviewed | 83 (75) | |
| Not documented or not performed | 28 (25) |
MCD, minimal change disease; MN, membranous nephropathy; SSNS/SRNS, steroid sensitive nephrotic syndrome, steroid resistant nephrotic syndrome; IQR, interquartile range.
Other primary etiologies included four patients with congenital nephrotic syndrome, one membranoproliferative glomerulonephritis, and one lipoprotein glomerulonephropathy.
Other secondary etiologies included two patients with interstitial nephritis, and one each of secondary nephrotic syndrome due to lymphoma, Alport syndrome, obstructive nephropathy, acute mediated rejection in transplant, immune complex glomerulonephritis, hemolytic uremic syndrome, and Kawasaki’s disease.