Figure 6. Repulsive effects of EFNA5 in human islets.

(A) Representative images and quantitation of pseudoislet formation of dispersed cells from human nondiabetic donor islets, after 4-day exposure to EFNA5-Fc or Fc control, at high (55 nM) or low (13.75 mM) dose. Data pooled from 3 independent experiments. (B) Representative images and quantitation of human β cells in EFNA5-Fc–coated condition (normalized to Fc control). Data shown as average of 3 independent experiments. Scale bars: 20 μm. All data are shown with group means; ***, P < 0.001 by 2-tailed t test.